This subtribe contains more than 1,300 species in 103 genera, including about 208 (38%) hybrid genera. They occur mostly in Asia with a few in Africa. They are distinguished from the other subtribes of Vandeae by having an entire rostellum, a relatively small spur formed by the lip, and four (or two) pollinia.
Some of the genera it contains have some of the largest and most spectacular flowers in the whole of the Orchid family. Also included in this subtribe are some of the most economically important genera in the horticultural trade, such as Phalaenopsis and Vanda.